Lithium Hexamethyldisilazide → 4-(4-(3,3-Diphenyl-2-propenyl)-1-piperazinyl)benzenecarboximidamide

Beteiligte Stoffe

Reaktionsschritte

A solution of EXAMPLE 12A (0.515 g, 1.36 mmol) in dry tetrahydrofuran (6 mL) was treated dropwise with LiHMDS (1M, 6.8 mL, 6.8 mmol), stirred for 16 hours, quenched with 1N HCl (8 mL), and filtered. The filter cake was collected to provide the desired product (0.45 g, 71%) that was used without further purification. MS (CI) m/e 397 (M+H)+.

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