Triethylamine → 4-[(3-fluoro-6-methylphenanthridin-5(6H)-yl)carbonyl]benzene-1,3-diol

Beteiligte Stoffe

Reaktionsschritte

N-1-(2′,4′-difluoro-1,1′-biphenyl-2-yl)ethyl]-2,4-dimethoxybenzamide—The title compound was prepared from 2,4-dimethoxybenzoyl chloride (860 mg, 4.28 mmol), 1-(-2′,4′-difluoro-biphenyl-2-yl)-ethylamine (1 g, 4.28 mmol), and triethylamine (717 uL, 5.1 mmol) according to the procedure and in the same manner as described in Example 33, step c resulting in the isolation of 1.47 g (86%) of a white solid. mp 134.8-135.2° C.; 1H NMR (400 MHz, DMSO-d6) δ ppm 1.29 (d, J=5.95 Hz, 3 H) 3.81 (s, 3 H) 3.92 (s, 3 H) 4.93 (d, J=6.73 Hz, 1 H) 6.59 (dd, J=8.79, 2.33 Hz, 1 H) 6.64 (d, J=2.33 Hz, 1 H) 7.18 (m, 2 H) 7.49 (m, 6 H) 8.29 (s, 1 H); MS (ESI) m/z 398 ([M+H]+); Anal. calcd for C23H21F2NO3: C:69.51 H:5.33 N:3.52 Found: C:69.27 H:5.30 N:3.39

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