(2E)-3-(2,6-Difluoro-4-methoxyphenyl)-2-propenoic Acid Ethyl Ester → Ethyl 3-(2,6-difluoro-4-methoxyphenyl)propanoate

HRID 732184Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 732184
[F:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[CH:5]=[C:4]([F:10])[C:3]=1/[CH:11]=[CH:12]/[C:13]([O:15][CH2:16][CH3:17])=[O:14]>O1CCCC1.C(O)C.[C].[Pd]>[F:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[CH:5]=[C:4]([F:10])[C:3]=1[CH2:11][CH2:12][C:13]([O:15][CH2:16][CH3:17])=[O:14]

Komponenten

5

Edukt 1

HCID 57636644(2E)-3-(2,6-Difluoro-4-methoxyphenyl)-2-propenoic Acid Ethyl Ester

Produkt 1

HCID 23082987Ethyl 3-(2,6-difluoro-4-methoxyphenyl)propanoateAusbeute 105,5 %

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 178418390HCID 178418390, VerbindungKatalysatorHCID 702EthanolLösungsmittelHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

Ethyl(2E)-3-(2,6-difluoro-4-methoxyphenyl)acrylate (1.1 g, 4.54 mmol) was dissolved in a mixed solvent of tetrahydrofuran (30 mL) and ethanol (30 mL), 10% palladium-carbon (0.30 g) was added and the mixture was stirred under a hydrogen atmosphere at room temperature for 5 hr. The catalyst was filtered off, and the obtained filtrate was concentrated to give the title compound (1.17 g, yield 100%) as a colorless oil.

Aufarbeitung

  1. additionwas added
  2. filtrationThe catalyst was filtered off
  3. concentrationthe obtained filtrate was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-847b0ebc4fe0460a8edcbc7f78928a1f
Quelldatensatz
uspto-grants-2009_09
Patentnummer
US07585880B2

Notizen zur Reaktion

Wird geladen…