Tert-butyl 3-(benzyloxycarbonylamino)-4-hydroxy-pyrrolidine-1-carboxylate → 1-Methyl-4-(methylamino)pyrrolidin-3-OL

HRID 732276

Reaktionsgleichung

Reaktionsgleichung von HRID 732276
[H-].[H-].[H-].[H-].[Li+].[Al+3].C(O[C:12]([N:14]1[CH2:18][CH:17]([OH:19])[CH:16]([NH:20][C:21](OCC2C=CC=CC=2)=O)[CH2:15]1)=O)(C)(C)C>C1COCC1>[CH3:12][N:14]1[CH2:15][CH:16]([NH:20][CH3:21])[CH:17]([OH:19])[CH2:18]1

Komponenten

4

Edukt 2

HCID 20691380Tert-butyl 3-(benzyloxycarbonylamino)-4-hydroxy-pyrrolidine-1-carboxylateHCID 21226445Aluminium lithium hydride

Produkt 1

HCID 684650761-Methyl-4-(methylamino)pyrrolidin-3-OLAusbeute 18 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

LAH (1.40 g, 35.0 mmol) is slowly added to a stirred solution of 3-benzyloxycarbonylamino-4-hydroxy-pyrrolidine-1-carboxylic acid tert-butyl ester in THF (15 ml) at room temperature. The reaction mixture is heated to reflux under N2 for 2 hours and then cooled to 0° C. The reaction mixture is quenched by the slow addition of Na2SO4.10H2O, warmed to room temperature, diluted with ethyl acetate and filtered through Celite. The filtrate is concentrated and purified on a silica gel column (10:1:0.5 methylene chloride, MeOH, 30% NH4OH solution) to yield 0.21 g (18% for two steps) 1-methyl-4-methylamino-pyrrolidin-3-ol.

Aufarbeitung

  1. temperatureThe reaction mixture is heated
  2. temperatureto reflux under N2 for 2 hours
  3. customThe reaction mixture is quenched by the slow addition of Na2SO4.10H2O
  4. temperaturewarmed to room temperature
  5. additiondiluted with ethyl acetate
  6. filtrationfiltered through Celite
  7. concentrationThe filtrate is concentrated
  8. custompurified on a silica gel column (10:1:0.5 methylene chloride, MeOH, 30% NH4OH solution)

Quellen und Nachweise

ORD-Eintrag
ord-517b1a151371432f8a873afce9e63243
Quelldatensatz
uspto-grants-2009_09
Patentnummer
US07585975B2

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