Dimethylformamide → 6-Chloro-N-{(3S)-1-[(1S)-1-methyl-2-morpholin-4-yl-2-oxoethyl]-2-oxopyrrolidin-3-yl}-N-(2-morpholin-4-ylethyl)naphthalene-2-sulfonamide formate

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	Dimethylformamide	HCID 6228	—
Edukt	Ethyl Acetate	HCID 8857	—
Edukt	Potassium Carbonate	HCID 11430	—
Edukt	Morpholine, 4-(2-chloroethyl)-, hydrochloride (1:1)	HCID 77210	—
Edukt	tert-Butyl(2R)-2-((3R)-3-{[(6-chloro-2-naphthyl)sulfonyl]amino}-2-oxopyrrolidin-1-yl)propanoate	HCID 69222335	—
Lösungsmittel	Water	HCID 962	—
Produkt	6-Chloro-N-{(3S)-1-[(1S)-1-methyl-2-morpholin-4-yl-2-oxoethyl]-2-oxopyrrolidin-3-yl}-N-(2-morpholin-4-ylethyl)naphthalene-2-sulfonamide formate	HCID 10189365	—

Reaktionsbedingungen

Temperatur	40 °C

Reaktionsschritte

Example 1 (0.05 g) was dissolved in DMF (1 ml) and treated with chloroethylmorpholine hydrochloride (0.062 g) and potassium carbonate (0.093 g), and stirred at 40° C. for 2 h. The mixture was then heated at 80° C. for 8 h, cooled and treated with ethyl acetate and water. The organic extraxt was dried (over magnesium sulphate) and concentrated under reduced pressure. The residue was purified using mass directed preparative h.p.l.c. to give the title compound (0.018 g) as a white solid.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US07084139B2
Quelldatensatz	uspto-grants-2006_08
ORD ID	ord-68e91174ffe545608aa7ac5a653e7839
Quellennotiz	uspto-grants-2006_08