Hydrochloric Acid → HCID 68814780, Verbindung

HRID 732561Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 732561
C[O:2][C:3](=[O:22])[C:4]1[CH:16]=[C:15](C(=O)C(C)C)[CH:14]=[C:6]([C:7]([N:9]([CH3:13])[CH2:10][CH2:11][CH3:12])=[O:8])[CH:5]=1.[OH-:23].[Na+].Cl>CO>[C:3]([C:5]1[C:6]([C:7]([N:9]([CH3:13])[CH2:10][CH2:11][CH3:12])=[O:8])=[CH:14][CH:15]=[CH:16][C:4]=1[C:3]([OH:2])=[O:22])(=[O:23])[CH:4]([CH3:16])[CH3:5]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 68814779HCID 68814779, Verbindung

Produkt 1

HCID 68814780HCID 68814780, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

Dissolve 5-isobutyryl-N-methyl-N-propyl-isophthalamic acid methyl ester (50 mg, 0.16 mmol) in methanol (3 mL) and add dropwise 2 N NaOH (0.16 mL). Stir the mixture at room temperature for 6 h, store overnight at 4° C. and acidify to about pH=6 by 5 N HCl. Concentrate to near dryness and dilute the residue with ethyl acetate. Wash with saturated aqueous sodium chloride solution and extract the organic layer, dry (magnesium sulfate) and concentrate to give the title compound.

Aufarbeitung

  1. waitstore overnight at 4° C.
  2. concentrationConcentrate
  3. additiondilute the residue with ethyl acetate
  4. washWash with saturated aqueous sodium chloride solution
  5. extractionextract the organic layer
  6. dry with materialdry (magnesium sulfate)
  7. concentrationconcentrate

Quellen und Nachweise

ORD-Eintrag
ord-2eb32b244a384d9fb7c9d3798f9a92d3
Quelldatensatz
uspto-grants-2009_09
Patentnummer
US07585885B2

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