HCID 6993579, Verbindung → HCID 68912232, Verbindung

HRID 732670Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 732670
C([N:8]1[CH2:12][C@H:11]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[CH3:19])[C@@H:10]([CH2:20][O:21][Si:22]([C:25]([CH3:28])([CH3:27])[CH3:26])([CH3:24])[CH3:23])[CH2:9]1)C1C=CC=CC=1.[C:29]([O:38][CH2:39][CH3:40])(=[O:37])[CH2:30][CH2:31][CH2:32][CH2:33][C:34]([O-:36])=O>>[Si:22]([O:21][CH2:20][C@@H:10]1[C@@H:11]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[CH3:19])[CH2:12][N:8]([C:34](=[O:36])[CH2:33][CH2:32][CH2:31][CH2:30][C:29]([O:38][CH2:39][CH3:40])=[O:37])[CH2:9]1)([C:25]([CH3:28])([CH3:27])[CH3:26])([CH3:23])[CH3:24]

Komponenten

3

Edukt 2

HCID 6993579HCID 6993579, VerbindungHCID 68915124HCID 68915124, Verbindung

Produkt 1

HCID 68912232HCID 68912232, Verbindung

Versuchsvorschrift

Using the (3R,4S)-1-benzyl-3-({[tert-butyl(dimethyl)silyl]oxy}methyl)-4-(2-methylphenyl)pyrrolidine obtained in Reference Example 127 which is described later, the elimination of benzyl group and amidation with monoethyl adipate were carried out in that order in the same manner as in Reference Example 16 and Reference Example 50 to produce ethyl 6-[(3R,4S)-3-({[tert-butyl(dimethyl)silyl]oxy}methyl)-4-(2-methylphenyl)pyrrolidin-1-yl]-6-oxohexanoate.

Aufarbeitung

  1. customobtained in Reference Example 127 which

Quellen und Nachweise

ORD-Eintrag
ord-ea9202b22d1345b199f58b383ab33466
Quelldatensatz
uspto-grants-2009_09
Patentnummer
US07585886B2

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