Ethyl 5-methyl-1-{6-[2-(trifluoromethoxy)phenyl]pyridin-2-yl}-1H-pyrazole-3-carboxylate → 5-methyl-1-{6-[2-(trifluoromethoxy)phenyl]pyridin-2-yl}-1H-pyrazole-3-carboxamide
Reaktionsgleichung
[CH3:1][C:2]1[N:6]([C:7]2[CH:12]=[CH:11][CH:10]=[C:9]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=3[O:19][C:20]([F:23])([F:22])[F:21])[N:8]=2)[N:5]=[C:4]([C:24]([O:26]CC)=O)[CH:3]=1.CO.[NH4+:31]>>[CH3:1][C:2]1[N:6]([C:7]2[CH:12]=[CH:11][CH:10]=[C:9]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=3[O:19][C:20]([F:23])([F:22])[F:21])[N:8]=2)[N:5]=[C:4]([C:24]([NH2:31])=[O:26])[CH:3]=1Komponenten
3
Versuchsvorschrift
A solution of the ester from Step 2 of EXAMPLE 137 (0.025 g, 0.064 mmol) in ammonium-methanol solution (7.0M, 3 mL) (placed in a sealed tube) was stirred at 70° C. for 2 days. After cooling, the reaction was concentrated to give the titled compound as yellow powder (0.02 g).
Aufarbeitung
- temperatureAfter cooling
- concentrationthe reaction was concentrated