Dimethylformamide → HCID 58437409, Verbindung

HRID 73323Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 73323
[CH2:1]([O:8][C:9]([C:11]1[CH:12]=[C:13]2[C:17](=[CH:18][CH:19]=1)[NH:16][CH:15]=[CH:14]2)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.P(Cl)(Cl)(Cl)=O.[OH-].[Na+].CN(C)[CH:29]=[O:30]>>[CH2:1]([O:8][C:9]([C:11]1[CH:12]=[C:13]2[C:17](=[CH:18][CH:19]=1)[NH:16][CH:15]=[C:14]2[CH:29]=[O:30])=[O:10])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Komponenten

5

Edukt 4

HCID 6228DimethylformamideHCID 14798Sodium HydroxideHCID 24813Phosphorus oxychlorideHCID 10264164Benzyl 1H-indole-5-carboxylate

Produkt 1

HCID 58437409HCID 58437409, Verbindung

Versuchsvorschrift

To a solution of 1H-indole-5-carboxylic acid benzyl ester (3.5 g) in N,N-dimethylformamide (30 mL) was added phosphoryl chloride (2.6 g) under ice cooling and this mixture was stirred at room temperature for 2 hours. To this reaction mixture was added 2 mol/L aqueous sodium hydroxide solution until the pH became 6 and this mixture was stirred at 70° C. for 30 minutes. After cooling to ambient temperature, the precipitated solid was collected by filtration, and washed with water and methanol, dried to give the title compound (3.9 g).

Aufarbeitung

  1. stirringthis mixture was stirred at 70° C. for 30 minutes
  2. temperatureAfter cooling to ambient temperature
  3. filtrationthe precipitated solid was collected by filtration
  4. washwashed with water and methanol
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-90bb0dc8680a45d29be8ab15104c07c2
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08829040B2

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