HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 7334Erstellt: 23. Oktober 2026
1-Bromo-4-iodobenzene → 1-Bromo-2',3'-difluoro-4'-ethoxybiphenyl
https://huagongshe.com/de/reaction/7334
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | 1-Bromo-4-iodobenzene | HCID 11522 | — |
| Edukt | Sodium metaborate | HCID 145326 | — |
| Edukt | B-(4-Ethoxy-2,3-difluorophenyl)boronic acid | HCID 15135235 | — |
| Edukt | Hydrazinium hydrochloride | HCID 21989311 | — |
| Katalysator | HCID 178418476 | HCID 178418476 | — |
| Lösungsmittel | Water | HCID 962 | — |
| Lösungsmittel | Tetrahydrofuran | HCID 8028 | — |
| Produkt | 1-Bromo-2',3'-difluoro-4'-ethoxybiphenyl | HCID 21989312 | — |
Reaktionsschritte
0.450 mol of sodium metaborate are introduced into 240 ml of water. 0.012 mol of bis(triphenylphosphine)palladium(II) chloride, 0.6 mol of 4-bromo-1-iodobenzene (11) and 0.012 mol of hydrazinium hydrochloride are added, and the mixture is stirred at about 20° C. for 5 minutes. 0.6 mol of 2,3-difluoro-4-ethoxyphenylboronic acid (12) dissolved in 600 ml of tetrahydrofuran are then added, and the mixture is refluxed for 4 hours, giving the compound of the formula 13.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patentnummer | US07087272B2 |
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| Quelldatensatz | uspto-grants-2006_08 |
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| ORD ID | ord-eca79e3229d14634afded7b73fa277ff |
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| Quellennotiz | uspto-grants-2006_08 |
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