Methanesulfonic Acid → HCID 86615209, Verbindung

Reaktionsgleichung

C(OC([N:8]1[C:12]2=[C:13]([Cl:26])[N:14]=[CH:15][C:16]([C:17](=[O:25])[NH:18][CH:19]3[CH2:24][CH2:23][O:22][CH2:21][CH2:20]3)=[C:11]2[C:10]([CH3:27])=[CH:9]1)=O)(C)(C)C.CS(O)(=O)=O.[CH:33]1([NH2:39])[CH2:38][CH2:37][CH2:36][CH2:35][CH2:34]1>C(OCC)(=O)C>[ClH:26].[O:22]1[CH2:21][CH2:20][CH:19]([NH:18][C:17]([C:16]2[C:11]3[C:10]([CH3:27])=[CH:9][NH:8][C:12]=3[C:13]([NH:39][CH:33]3[CH2:38][CH2:37][CH2:36][CH2:35][CH2:34]3)=[N:14][CH:15]=2)=[O:25])[CH2:24][CH2:23]1

Komponenten

Versuchsvorschrift

Prepared in a similar manner to Example 12, from 7-chloro-3-methyl-4-(tetrahydro-pyran-4-ylcarbamoyl)-pyrrolo[2,3-c]pyridine-1-carboxylic acid tert-butyl ester except that the methanesulfonic acid was omitted. Cyclohexylamine (900 ul) was used and the reaction time was 15 h. Ethyl acetate was used instead of dichloromethane as solvent in the work up, no chromatography was required, and ethyl acetate was used instead of dichloromethane in the salt formation, to give the title compound (13 mg).