Cesium carbonate → {2-[1-(2,3-Dimethylphenyl)ethyl]-1h-imidazol-1-yl}methyl propionate

HRID 734452

Reaktionsgleichung

Reaktionsgleichung von HRID 734452
[CH3:1][C:2]1[C:7]([CH3:8])=[CH:6][CH:5]=[CH:4][C:3]=1[CH:9]([C:11]1[NH:12][CH:13]=[CH:14][N:15]=1)[CH3:10].C(=O)([O-])[O-].[Cs+].[Cs+].[C:22]([O:26][CH2:27]Cl)(=[O:25])[CH2:23][CH3:24]>CC(C)=O>[C:22]([O:26][CH2:27][N:15]1[CH:14]=[CH:13][N:12]=[C:11]1[CH:9]([C:3]1[CH:4]=[CH:5][CH:6]=[C:7]([CH3:8])[C:2]=1[CH3:1])[CH3:10])(=[O:25])[CH2:23][CH3:24]

Komponenten

5

Edukt 3

HCID 10796Cesium carbonateHCID 221144Chloromethyl propionateHCID 216625422-(1-(2,3-Dimethylphenyl)ethyl)-1H-imidazole

Produkt 1

HCID 24738940{2-[1-(2,3-Dimethylphenyl)ethyl]-1h-imidazol-1-yl}methyl propionate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

To a suspension of the compound of Example 1 (120 mg, 0.6 mmol) and caesium carbonate (731 mg, 1.8 mmol) in acetone (4 ml), under nitrogen, was added chloromethyl propionate (Eur. J. Pharm. Sci: 24; 5; 2005; 433-440, 183 mg, 1.5 mmol) and the reaction mixture was stirred at room temperature for 18 h. The mixture was filtered and the filtrate was concentrated in vacuo.

Aufarbeitung

  1. filtrationThe mixture was filtered
  2. concentrationthe filtrate was concentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-87da69cc771e476499aa674037b88290
Quelldatensatz
uspto-grants-2009_09
Patentnummer
US07592362B2

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