Methanol → HCID 13318612, Verbindung

HRID 734730Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 734730
[NH2:1][S:2]([C:5]1[C:6]([Cl:15])=[CH:7][C:8]([F:14])=[C:9]([CH:13]=1)[C:10]([OH:12])=[O:11])(=[O:4])=[O:3].[CH3:16]O>S(=O)(=O)(O)O.CCOC(C)=O>[NH2:1][S:2]([C:5]1[C:6]([Cl:15])=[CH:7][C:8]([F:14])=[C:9]([CH:13]=1)[C:10]([O:12][CH3:16])=[O:11])(=[O:3])=[O:4]

Komponenten

5

Edukt 2

HCID 887MethanolHCID 124625724-Chloro-2-fluoro-5-sulfamoylbenzoic acid

Produkt 1

HCID 13318612HCID 13318612, VerbindungAusbeute 95 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 1118Sulfuric AcidKatalysatorHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

5-(Aminosulfonyl)-4-chloro-2-fluorobenzoic acid (507 mg, 2.0 mmol) in CH3OH (3 mL) with 3 drops of concentrated sulfuric acid was heated at 80° C. for 60 hours. The reaction mixture was diluted with EtOAc (20 mL), washed with water, brine, and dried (Na2SO4). The solvent was evaporated to afford the product (508 mg, 95%) as a white solid. MS (ES+) m/z 268 [M+H]+.

Aufarbeitung

  1. washwashed with water, brine
  2. dry with materialdried (Na2SO4)
  3. customThe solvent was evaporated

Quellen und Nachweise

ORD-Eintrag
ord-6b6ebbc1a3f14e38b56bd92dc5659ec0
Quelldatensatz
uspto-grants-2009_09
Patentnummer
US07592357B2

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