Methanol → Methyl 4-chloro-3-sulfamoylbenzoate

HRID 734733

Reaktionsgleichung

Reaktionsgleichung von HRID 734733
[NH2:1][S:2]([C:5]1[CH:6]=[C:7]([CH:11]=[CH:12][C:13]=1[Cl:14])[C:8]([OH:10])=[O:9])(=[O:4])=[O:3].[CH3:15]O>S(=O)(=O)(O)O.CCOC(C)=O>[NH2:1][S:2]([C:5]1[CH:6]=[C:7]([CH:11]=[CH:12][C:13]=1[Cl:14])[C:8]([O:10][CH3:15])=[O:9])(=[O:4])=[O:3]

Komponenten

5

Edukt 2

HCID 887MethanolHCID 145684-Chloro-3-sulfamoylbenzoic acid

Produkt 1

HCID 4277179Methyl 4-chloro-3-sulfamoylbenzoateAusbeute 95 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 1118Sulfuric AcidKatalysatorHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

3-(Aminosulfonyl)-4-chlorobenzoic acid (943 mg, 4.0 mmol) was heated at 70° C. in CH3OH (10 mL) with 3 drops of concentrated sulfuric acid for 34 hours. The reaction mixture was diluted with EtOAc (20 mL), washed with water, brine, and dried (Na2SO4). The solvent was evaporated to afford the product (950 mg, 95%) as a white solid. MS (ES+) m/z 250 [M+H]+.

Aufarbeitung

  1. washwashed with water, brine
  2. dry with materialdried (Na2SO4)
  3. customThe solvent was evaporated

Quellen und Nachweise

ORD-Eintrag
ord-2ba078ff6fe9468996bc53adcbb229cd
Quelldatensatz
uspto-grants-2009_09
Patentnummer
US07592357B2

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