Methanol → Benzoic acid, 3-(aminosulfonyl)-, methyl ester

HRID 734736

Reaktionsgleichung

Reaktionsgleichung von HRID 734736
[NH2:1][S:2]([C:5]1[CH:6]=[C:7]([CH:11]=[CH:12][CH:13]=1)[C:8]([OH:10])=[O:9])(=[O:4])=[O:3].[CH3:14]O>S(=O)(=O)(O)O.CCOC(C)=O>[NH2:1][S:2]([C:5]1[CH:6]=[C:7]([CH:11]=[CH:12][CH:13]=1)[C:8]([O:10][CH3:14])=[O:9])(=[O:3])=[O:4]

Komponenten

5

Edukt 2

HCID 887MethanolHCID 2293523-Sulfamoylbenzoic acid

Produkt 1

HCID 108836Benzoic acid, 3-(aminosulfonyl)-, methyl esterAusbeute 98 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 1118Sulfuric AcidKatalysatorHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

3-(Aminosulfonyl)benzoic acid (603 mg, 3.0 mmol) was heated at 80° C. in CH3OH (3 mL) with 3 drops of concentrated sulfuric acid for 60 hours. The reaction mixture was diluted with EtOAc (20 mL), washed with water, brine, and dried (Na2SO4). The solvent was evaporated to afford the product (630 mg, 98%) as a white solid. MS (ES+) m/z 216 [M+H]+.

Aufarbeitung

  1. washwashed with water, brine
  2. dry with materialdried (Na2SO4)
  3. customThe solvent was evaporated

Quellen und Nachweise

ORD-Eintrag
ord-a4b72a81d93e43e8aa724688c2f86acf
Quelldatensatz
uspto-grants-2009_09
Patentnummer
US07592357B2

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