HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
p-Formylphenylboric acid → 4-(6-{4-[2-(4-Methylpiperidin-1-yl)ethoxy]phenylethynyl}pyridin-3-yl)benzaldehyde
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | p-Formylphenylboric acid | HCID 21940015 | — |
| Edukt | 5-Bromo-2-{4-[2-(4-methylpiperidin-1-yl)ethoxy]phenylethynyl}pyridine | HCID 69060172 | — |
| Lösungsmittel | Dichloromethane methanol | HCID 21226129 | — |
| Produkt | 4-(6-{4-[2-(4-Methylpiperidin-1-yl)ethoxy]phenylethynyl}pyridin-3-yl)benzaldehyde | HCID 57845295 | — |
Reaktionsschritte
The product was obtained analogously to Example 1.1e starting from 5-bromo-2-{4-[2-(4-methylpiperidin-1-yl)ethoxy]phenylethynyl}pyridine and 4-formylphenylboric acid. Yield: 0.20 g (47% of theoretical); C28H28N2O2 (M=424.534); calc.: molpeak (M+H)+425; found: molpeak (M+H)+: 425; Rf value: 0.40 (silica gel, DCM/MeOH 9:1).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07592358B2 |
| Quelldatensatz | uspto-grants-2009_09 |
| ORD ID | ord-15ba0b71536643f1b117aabb498c32f7 |
| Quellennotiz | uspto-grants-2009_09 |