3-Aminobenzamide → 2-(3-Carbamoylphenylamino)-2-(4-(2-(3-(3-cyanophenyl)-1-methylureido)ethyl)phenyl)acetic acid
Reaktionsgleichung
[C:1]([C:3]1[CH:4]=[C:5]([NH:9][C:10](=[O:24])[N:11]([CH2:13][CH2:14][C:15]2[CH:20]=[CH:19][C:18](B(O)O)=[CH:17][CH:16]=2)[CH3:12])[CH:6]=[CH:7][CH:8]=1)#[N:2].[NH2:25][C:26]1[CH:27]=[C:28]([CH:32]=[CH:33][CH:34]=1)[C:29]([NH2:31])=[O:30].O.[C:36]([OH:40])(=[O:39])[CH:37]=O>>[C:29]([C:28]1[CH:27]=[C:26]([NH:25][CH:37]([C:18]2[CH:19]=[CH:20][C:15]([CH2:14][CH2:13][N:11]([CH3:12])[C:10]([NH:9][C:5]3[CH:6]=[CH:7][CH:8]=[C:3]([C:1]#[N:2])[CH:4]=3)=[O:24])=[CH:16][CH:17]=2)[C:36]([OH:40])=[O:39])[CH:34]=[CH:33][CH:32]=1)(=[O:30])[NH2:31]Komponenten
4
Versuchsvorschrift
Using a procedure analogous to that used to prepare 2D, 23D (170 mg, 0.52 mmol) was reacted with 3-aminobenzamide and glyoxylic acid monohydrate to afford 58A (157 mg, 64%) as an oil. MS (ESI) m/z 472.3 (M+H)+.