1-Bromo-4-(methylsulphonyl)benzene → 4-(4-Methanesulfonyl-phenyl)piperazine-1-carboxylic acid tert-butyl ester

HRID 736177

Reaktionsgleichung

Reaktionsgleichung von HRID 736177
[CH3:1][S:2]([C:5]1[CH:10]=[CH:9][C:8](Br)=[CH:7][CH:6]=1)(=[O:4])=[O:3].[C:12]([N:19]1[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]1)([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:13]>>[C:15]([O:14][C:12]([N:19]1[CH2:24][CH2:23][N:22]([C:8]2[CH:9]=[CH:10][C:5]([S:2]([CH3:1])(=[O:4])=[O:3])=[CH:6][CH:7]=2)[CH2:21][CH2:20]1)=[O:13])([CH3:18])([CH3:16])[CH3:17]

Komponenten

3

Edukt 2

HCID 770141-Bromo-4-(methylsulphonyl)benzeneHCID 143452tert-Butyl piperazine-1-carboxylate

Produkt 1

HCID 597935014-(4-Methanesulfonyl-phenyl)piperazine-1-carboxylic acid tert-butyl ester

Versuchsvorschrift

The title compound was prepared according to the procedure described for example AX from 4-bromophenyl methyl sulfone and N-Boc-piperazine (31%, white solid, MS (m/e): 241.2 (M−Boc, 100%)

Quellen und Nachweise

ORD-Eintrag
ord-9fe652b2e94f4b6a81352d98e255bda7
Quelldatensatz
uspto-grants-2009_09
Patentnummer
US07595314B2

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