1-(3-Fluoro-4-piperazin-1-ylphenyl)ethanone → 1-{3-Fluoro-4-[4-(5-methylsulfanyl-2-morpholin-4-yl-benzoyl)-piperazin-1-yl]-phenyl}-ethanone

HRID 736193

Reaktionsgleichung

Reaktionsgleichung von HRID 736193
[CH3:1][S:2][C:3]1[CH:4]=[CH:5][C:6]([N:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)=[C:7]([CH:11]=1)[C:8]([OH:10])=O.[F:18][C:19]1[CH:20]=[C:21]([C:31](=[O:33])[CH3:32])[CH:22]=[CH:23][C:24]=1[N:25]1[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]1>>[F:18][C:19]1[CH:20]=[C:21]([C:31](=[O:33])[CH3:32])[CH:22]=[CH:23][C:24]=1[N:25]1[CH2:30][CH2:29][N:28]([C:8](=[O:10])[C:7]2[CH:11]=[C:3]([S:2][CH3:1])[CH:4]=[CH:5][C:6]=2[N:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)[CH2:27][CH2:26]1

Komponenten

3

Edukt 2

HCID 6856101-(3-Fluoro-4-piperazin-1-ylphenyl)ethanoneHCID 597935765-Methylsulfanyl-2-morpholin-4-yl-benzoic acid

Produkt 1

HCID 597934981-{3-Fluoro-4-[4-(5-methylsulfanyl-2-morpholin-4-yl-benzoyl)-piperazin-1-yl]-phenyl}-ethanone

Versuchsvorschrift

The title compound was prepared according to the procedure described for example K step 2 from 5-Methylsulfanyl-2-morpholin-4-yl-benzoic acid and 1-(3-Fluoro-4-piperazin-1-yl-phenyl)-ethanone (8%, white solid), MS (m/e): 458.2 (M+, 100%)

Quellen und Nachweise

ORD-Eintrag
ord-5bff971795184e8d97eefb2cdf71ff1f
Quelldatensatz
uspto-grants-2009_09
Patentnummer
US07595314B2

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