1-(4-(Trifluoromethyl)phenyl)piperazine → 3,4-Difluoro-N-methyl-5-[4-(4-trifluoromethyl-phenyl)-piperazine-1-carbonyl]-benzenesulfonamide

HRID 736220Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 736220
[F:1][C:2]1[C:10]([F:11])=[CH:9][C:8]([S:12](=[O:16])(=[O:15])[NH:13][CH3:14])=[CH:7][C:3]=1[C:4]([OH:6])=O.[F:17][C:18]([F:32])([F:31])[C:19]1[CH:24]=[CH:23][C:22]([N:25]2[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]2)=[CH:21][CH:20]=1>>[F:11][C:10]1[CH:9]=[C:8]([S:12]([NH:13][CH3:14])(=[O:16])=[O:15])[CH:7]=[C:3]([C:4]([N:28]2[CH2:27][CH2:26][N:25]([C:22]3[CH:21]=[CH:20][C:19]([C:18]([F:31])([F:32])[F:17])=[CH:24][CH:23]=3)[CH2:30][CH2:29]2)=[O:6])[C:2]=1[F:1]

Komponenten

3

Edukt 2

HCID 1217181-(4-(Trifluoromethyl)phenyl)piperazineHCID 688392472,3-Difluoro-5-methylsulfamoyl-benzoic acid

Produkt 1

HCID 597935643,4-Difluoro-N-methyl-5-[4-(4-trifluoromethyl-phenyl)-piperazine-1-carbonyl]-benzenesulfonamide

Versuchsvorschrift

The title compound was prepared in analogy to Example BO by reaction of 2,3-Difluoro-5-methylsulfamoyl-benzoic acid and 1-(4-trifluoromethylphenyl)piperazine (ABCR F07741NB, [30459-17-7]) to yield the title compound as a light yellow amorpous solid. (m/e): 462.1 (M−H, 100%).

Quellen und Nachweise

ORD-Eintrag
ord-e3ccc4d7b913426cadc3d7e53e7f47df
Quelldatensatz
uspto-grants-2009_09
Patentnummer
US07595314B2

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