Methanesulfonic Acid → 4-(4-methylpiperazin-N-ylaminomethyl)-N-[4-methyl-3-(4-(pyridin-3-yl)pyrimidin-2-yl)aminophenyl]benzamide methanesulfonate

HRID 736299Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 736299
[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([NH:8][CH2:9][C:10]2[CH:38]=[CH:37][C:13]([C:14]([NH:16][C:17]3[CH:22]=[CH:21][C:20]([CH3:23])=[C:19]([NH:24][C:25]4[N:30]=[C:29]([C:31]5[CH:32]=[N:33][CH:34]=[CH:35][CH:36]=5)[CH:28]=[CH:27][N:26]=4)[CH:18]=3)=[O:15])=[CH:12][CH:11]=2)[CH2:4][CH2:3]1.[CH3:39][S:40]([OH:43])(=[O:42])=[O:41]>C(O)C>[CH3:39][S:40]([OH:43])(=[O:42])=[O:41].[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([NH:8][CH2:9][C:10]2[CH:38]=[CH:37][C:13]([C:14]([NH:16][C:17]3[CH:22]=[CH:21][C:20]([CH3:23])=[C:19]([NH:24][C:25]4[N:30]=[C:29]([C:31]5[CH:32]=[N:33][CH:34]=[CH:35][CH:36]=5)[CH:28]=[CH:27][N:26]=4)[CH:18]=3)=[O:15])=[CH:12][CH:11]=2)[CH2:4][CH2:3]1

Komponenten

4

Edukt 2

HCID 6395Methanesulfonic AcidHCID 98924924-(4-methylpiperazin-1-ylaminomethyl)-N-[4-methyl-3-(4-(pyridin-3-yl)pyrimidin-2-yl)aminophenyl]benzamide

Produkt 1

HCID 865953404-(4-methylpiperazin-N-ylaminomethyl)-N-[4-methyl-3-(4-(pyridin-3-yl)pyrimidin-2-yl)aminophenyl]benzamide methanesulfonateAusbeute 70,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

4-(4-Methylpiperazin-1-ylaminomethyl)-N-[4-methyl-3-(4-(pyridin-3-yl)pyrimidin-2-yl)aminophenyl]benzamide (95 mg, 0.187 mmol) was dissolved in ethanol (8 ml), methanesulfonic acid (24 μl, 0.347 mmol) was added thereto, and the mixture was reacted at room temperature for 16 hours. The resulting solid was filtered and washed with acetone to give 4-(4-methylpiperazin-N-ylaminomethyl)-N-[4-methyl-3-(4-(pyridin-3-yl)pyrimidin-2-yl)aminophenyl]benzamide methanesulfonate (80 mg).

Aufarbeitung

  1. customthe mixture was reacted at room temperature for 16 hours
  2. filtrationThe resulting solid was filtered
  3. washwashed with acetone

Quellen und Nachweise

ORD-Eintrag
ord-9427bd5b76ad4c588b5d29eb1c252ac1
Quelldatensatz
uspto-grants-2009_09
Patentnummer
US07595323B2

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