HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Acetonitrile → 1-(4-Bromo-benzyl)-3-phenyl-piperidine
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Acetonitrile | HCID 6342 | — |
| Edukt | Potassium Carbonate | HCID 11430 | — |
| Edukt | 4-Bromobenzyl bromide | HCID 68527 | — |
| Edukt | 2-Phenylpiperidine | HCID 103020 | — |
| Produkt | 1-(4-Bromo-benzyl)-3-phenyl-piperidine | HCID 57849571 | 54% |
Reaktionsschritte
5.632 g of 4-Bromobenzyl bromide and 2.422 g of 2-Phenylpiperidine (Array) in 50 mL of acetonitrile were stirred at room temperature and 6.229 g of potassium carbonate was added. The reaction was stirred at room temperature overnight. The solution was filtered through Celite and concentrated in vacuo to afford a brown solid. Purification was done by flash chromatography to afford product. Wt:0.908 g, 54% yield.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07595397B2 |
| Quelldatensatz | uspto-grants-2009_09 |
| ORD ID | ord-34fa2b02ab2e469ea65d7e888a05af06 |
| Quellennotiz | uspto-grants-2009_09 |