Potassium Carbonate → HCID 57849627, Verbindung

HRID 737109Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 737109
[Br:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6]Br)=[CH:4][CH:3]=1.[CH:10]([CH:13]1[O:18][CH2:17][CH2:16][NH:15][CH2:14]1)([CH3:12])[CH3:11].C(=O)([O-])[O-].[K+].[K+]>C(#N)C>[Br:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][N:15]2[CH2:16][CH2:17][O:18][CH:13]([CH:10]([CH3:12])[CH3:11])[CH2:14]2)=[CH:4][CH:3]=1

Komponenten

5

Edukt 3

HCID 11430Potassium CarbonateHCID 685274-Bromobenzyl bromideHCID 198776882-(Propan-2-yl)morpholine

Produkt 1

HCID 57849627HCID 57849627, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

The above compound could be made in the following manner: 1.5 eq. of 4-Bromobenzyl bromide and 1 eq. of 2-Isopropyl-morpholine in acetonitrile could be stirred at room temperature and 3 eq. of potassium carbonate could be added. The reaction could be stirred at room temperature overnight. The solution could be filtered through Celite and concentrated in vacuo to afford a brown solid. Purification could be done by flash chromatography to afford product.

Aufarbeitung

  1. customThe reaction
  2. filtrationThe solution could be filtered through Celite
  3. concentrationconcentrated in vacuo
  4. customto afford a brown solid
  5. customPurification
  6. customto afford product

Quellen und Nachweise

ORD-Eintrag
ord-f76af3ff5147415eb43327fcda4bf1bd
Quelldatensatz
uspto-grants-2009_09
Patentnummer
US07595397B2

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