(S)-2-[4-(4-Cyclopropylcarbamoyl-phenyl)-thiazol-2-ylcarbamoyl]-thiazolidine-3-carboxylic acid tert-butyl ester → (S)-Thiazolidine-2-carboxylic acid [4-(4-cyclopropylcarbamoyl-phenyl)-thiazol-2-yl]-amide

HRID 737185Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 737185
C(OC([N:8]1[CH2:12][CH2:11][S:10][C@H:9]1[C:13](=[O:32])[NH:14][C:15]1[S:16][CH:17]=[C:18]([C:20]2[CH:25]=[CH:24][C:23]([C:26](=[O:31])[NH:27][CH:28]3[CH2:30][CH2:29]3)=[CH:22][CH:21]=2)[N:19]=1)=O)(C)(C)C>ClCCl.FC(F)(F)C(O)=O>[CH:28]1([NH:27][C:26]([C:23]2[CH:22]=[CH:21][C:20]([C:18]3[N:19]=[C:15]([NH:14][C:13]([C@H:9]4[NH:8][CH2:12][CH2:11][S:10]4)=[O:32])[S:16][CH:17]=3)=[CH:25][CH:24]=2)=[O:31])[CH2:30][CH2:29]1

Komponenten

4

Edukt 1

HCID 57849787(S)-2-[4-(4-Cyclopropylcarbamoyl-phenyl)-thiazol-2-ylcarbamoyl]-thiazolidine-3-carboxylic acid tert-butyl ester

Produkt 1

HCID 86616434(S)-Thiazolidine-2-carboxylic acid [4-(4-cyclopropylcarbamoyl-phenyl)-thiazol-2-yl]-amide

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6344DichloromethaneLösungsmittelHCID 6422Trifluoroacetic acidLösungsmittel

Versuchsvorschrift

A solution of (S)-2-[4-(4-cyclopropylcarbamoyl-phenyl)-thiazol-2-ylcarbamoyl]-thiazolidine-3-carboxylic acid tert-butyl ester (341.6 mg, 0.72 mmol) in dichloromethane (3 mL) and trifluoroacetic acid (3 mL) was stirred at ambient temperature overnight. The reaction was filtered and purified by reverse phase HPLC to give the desired product.

Aufarbeitung

  1. filtrationThe reaction was filtered
  2. custompurified by reverse phase HPLC

Quellen und Nachweise

ORD-Eintrag
ord-4c5de14eb8514bbfb6e839cc74ede4a5
Quelldatensatz
uspto-grants-2009_09
Patentnummer
US07595398B2

Notizen zur Reaktion

Wird geladen…