2-Tert-Butylphenol → 4-Bromo-2-tert-butylphenol

HRID 73996

Reaktionsgleichung

Reaktionsgleichung von HRID 73996
[C:1]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[OH:11])([CH3:4])([CH3:3])[CH3:2].C1C(=O)N([Br:19])C(=O)C1>CC#N>[C:1]([C:5]1[CH:10]=[C:9]([Br:19])[CH:8]=[CH:7][C:6]=1[OH:11])([CH3:4])([CH3:2])[CH3:3]

Komponenten

4

Edukt 2

HCID 69232-Tert-ButylphenolHCID 67184N-bromobutanimide

Produkt 1

HCID 970684-Bromo-2-tert-butylphenolAusbeute 99,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

To a solution of 2-tert-butylphenol (250 g, 1.67 mol) in CH3CN (1500 mL) was added NBS (300 g, 1.67 mol) at room temperature. After addition, the mixture was stirred at room temperature overnight and then the solvent was removed. Petroleum ether (1000 mL) was added, and the resulting white precipitate was filtered off. The filtrate was concentrated under reduced pressure to give the crude 2-tert-butyl-4-bromophenol (380 g), which was used without further purification.

Aufarbeitung

  1. additionAfter addition
  2. customthe solvent was removed
  3. additionPetroleum ether (1000 mL) was added
  4. filtrationthe resulting white precipitate was filtered off
  5. concentrationThe filtrate was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-97ca45fe2d5043acb3e89dba7009a4e9
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08829204B2

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