Acetic acid, 2-oxo-, methyl ester → methyl (2E)-2-[(2-chlorophenyl)hydrazinylidene]acetate

HRID 7404

Reaktionsgleichung

Reaktionsgleichung von HRID 7404
[C:1]([O:5][CH3:6])(=[O:4])[CH:2]=O.Cl.[Cl:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[NH:15][NH2:16]>CO>[Cl:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[NH:15]/[N:16]=[CH:2]/[C:1]([O:5][CH3:6])=[O:4]

Komponenten

4

Edukt 2

HCID 70205Acetic acid, 2-oxo-, methyl esterHCID 4432872-Chlorophenylhydrazine hydrochloride

Produkt 1

HCID 19868318methyl (2E)-2-[(2-chlorophenyl)hydrazinylidene]acetate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

To a solution of methyl glyoxylate (6.8 g, 77 mmol) in methanol (150 mL) was added 2-chlorophenylhydrazine hydrochloride (12.5 g, 77 mmol) and the mixture was heated at reflux overnight, cooled and concentrated. The residue was re-dissolved in toluene and concentrated to give the title compound of Step A.

Aufarbeitung

  1. temperaturethe mixture was heated
  2. temperatureat reflux overnight
  3. temperaturecooled
  4. concentrationconcentrated
  5. dissolutionThe residue was re-dissolved in toluene
  6. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-a1a53def4c664a96999097c0e8311779
Quelldatensatz
uspto-grants-2006_08
Patentnummer
US07087598B2

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