Triethylamine → Acetamide, N-[(2-bromophenyl)methyl]-2,2,2-trifluoro-

HRID 74091

Reaktionsgleichung

Reaktionsgleichung von HRID 74091
[Br:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH2:4][NH2:5].[F:10][C:11]([F:18])([F:17])[C:12](OCC)=[O:13].C(N(CC)CC)C>CO>[Br:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH2:4][NH:5][C:12](=[O:13])[C:11]([F:18])([F:17])[F:10]

Komponenten

5

Edukt 3

HCID 8471TriethylamineHCID 9794Ethyl trifluoroacetateHCID 3340722-Bromobenzylamine

Produkt 1

HCID 57470274Acetamide, N-[(2-bromophenyl)methyl]-2,2,2-trifluoro-Ausbeute 103,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

To a solution of 2-bromobenzylamine (1.3 mL, 10.8 mmol) in methanol (5 mL) was added ethyl trifluoroacetate (1.54 mL, 21.6 mmol) and triethylamine (1.4 mL, 10.8 mmol) under a nitrogen atmosphere. The reaction was stirred at room temperature for 1 h. The reaction mixture was then concentrated under vacuum to yield N-(2-bromo-benzyl)-2,2,2-trifluoro-acetamide (3.15 g, quant.). HPLC ret. time 2.86 min, 10-99% CH3CN, 5 min run; ESI-MS 283.9 m/z (MH+).

Aufarbeitung

  1. concentrationThe reaction mixture was then concentrated under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-a58ea110164e4951bae5340068fc0d41
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08829204B2

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