Indoline → HCID 178418799, Verbindung

HRID 7414

Reaktionsgleichung

Reaktionsgleichung von HRID 7414
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][CH2:2]1.CS[C:12]1[N:17]=[C:16]([OH:18])[C:15]([C:19]([O:21][CH2:22][CH3:23])=[O:20])=[CH:14][N:13]=1>C(O)C>[OH:18][C:16]1[C:15]([C:19]([O:21][CH2:22][CH3:23])=[O:20])=[CH:14][N:13]=[C:12]([N:1]2[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[CH2:3][CH2:2]2)[N:17]=1

Komponenten

4

Edukt 2

HCID 10328IndolineHCID 178418871HCID 178418871, Verbindung

Produkt 1

HCID 178418799HCID 178418799, VerbindungAusbeute 77,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

To a solution of indoline (3.58 g, 30 mmol) in ethanol (50 mL) was added ethyl 2-methylthio-4-hydroxypyrimidine-5-carboxylate (5.35 g, 25 mmol) and the mixture was heated under reflux for 18 h. The reaction mixture was allowed to cool to room temperature and the precipitated crystals were collected by filtration. The crystals were washed several times with cold ethanol and dried to give the title compound (5.5 g, 77%) as crystals.

Aufarbeitung

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 18 h
  3. filtrationthe precipitated crystals were collected by filtration
  4. washThe crystals were washed several times with cold ethanol
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-b3ebf651e99d40be9d11ee0c8e9016bb
Quelldatensatz
uspto-grants-2006_08
Patentnummer
US07087597B1

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