Triethylamine → 3-(2-Ethyl-6-isopropylphenyl)-1-methyl-2-thioxo-imidazolidin-4-one

HRID 742233

Reaktionsgleichung

Reaktionsgleichung von HRID 742233
[CH2:1]([C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([CH:9]([CH3:11])[CH3:10])[C:4]=1[N:12]=[C:13]=[S:14])[CH3:2].Cl.C([O:18][C:19](=O)[CH2:20][NH:21][CH3:22])C.C(N(CC)CC)C>C(Cl)(Cl)Cl>[CH2:1]([C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([CH:9]([CH3:11])[CH3:10])[C:4]=1[N:12]1[C:19](=[O:18])[CH2:20][N:21]([CH3:22])[C:13]1=[S:14])[CH3:2]

Komponenten

5

Edukt 3

HCID 8471TriethylamineHCID 1442342-Ethyl-6-isopropylphenyl isothiocyanateHCID 171173Ethyl N-methylaminoacetate hydrochloride

Produkt 1

HCID 857014693-(2-Ethyl-6-isopropylphenyl)-1-methyl-2-thioxo-imidazolidin-4-oneAusbeute 64,9 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel

Versuchsvorschrift

The title compound was prepared by the procedure described in Example 1 using 10.25 g of 2-ethyl-6-isopropylphenyl-isothiocyanate, 7.68 g of sarcosine ethyl ester hydrochloride, 14.8 g of triethyl amine, and 200 mL of chloroform. Crystallization from diethyl ether/hexane mixture afforded the title compound (8.95 g) as a tan solid, m.p. 132°-134° C. Anal. Calcd. for C15H20N2O S: C, 65.18; H, 7.29; N, 10.13. Found: C, 65.11; H, 7.31; N, 10.05. Mass spectrum (PBEI, M.+) m/z 276.

Aufarbeitung

  1. customThe title compound was prepared by the procedure
  2. customCrystallization from diethyl ether/hexane mixture

Quellen und Nachweise

ORD-Eintrag
ord-7fe1c1abbd9c4663a47576548c5451dc
Quelldatensatz
uspto-grants-1996_09
Patentnummer
US05554607

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