Triethylamine → 1-Ethyl-2-thioxo-3-(2,4,5-trimethylphenyl)-imidazolidin-4-one

HRID 742261

Reaktionsgleichung

Reaktionsgleichung von HRID 742261
[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])[C:5]([CH3:9])=[CH:4][C:3]=1[N:10]=[C:11]=[S:12].[CH2:13]([NH:15][CH2:16][C:17](O)=[O:18])[CH3:14].C(N(CC)CC)C>C(Cl)(Cl)Cl>[CH2:13]([N:15]1[CH2:16][C:17](=[O:18])[N:10]([C:3]2[CH:4]=[C:5]([CH3:9])[C:6]([CH3:8])=[CH:7][C:2]=2[CH3:1])[C:11]1=[S:12])[CH3:14]

Komponenten

5

Edukt 3

HCID 8471TriethylamineHCID 1405012,4,5-Trimethylphenyl isothiocyanateHCID 316542N-Ethylglycine

Produkt 1

HCID 113574921-Ethyl-2-thioxo-3-(2,4,5-trimethylphenyl)-imidazolidin-4-oneAusbeute 58,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel

Versuchsvorschrift

The title compound was prepared by the procedure described in Example 16 using 17.7 g of 2,4,5-trimethylphenyl-isothiocyanate, 18.4 g of N-ethyl glycine, 20.2 g of triethyl amine, and 250 mL of chloroform. Crystallization from ethanol afforded the title compound (15.3g) as an off-white solid, m.p. 162°-164° C. Anal. Calcd. for. C14H18N2O S: C,64.09; H, 6.92; N, 10.68. Found: C, 64.21; H, 6.93; N, 10.80. Mass spectrum (EI, M.+) m/z 262.

Aufarbeitung

  1. customThe title compound was prepared by the procedure
  2. customCrystallization from ethanol

Quellen und Nachweise

ORD-Eintrag
ord-9af578eb834c4bd482adb927dabf24cf
Quelldatensatz
uspto-grants-1996_09
Patentnummer
US05554607

Verknüpfte Notizen

Wird geladen…