Triethylamine → 3-(2-Ethyl-6-methylphenyl)-1-isopropyl-2-thioxo-imidazolidin-4-one

HRID 742271Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 742271
[CH2:1]([C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([CH3:9])[C:4]=1[N:10]=[C:11]=[S:12])[CH3:2].[CH:13]([NH:16][CH2:17][C:18](O)=[O:19])([CH3:15])[CH3:14].C(N(CC)CC)C>C(Cl)(Cl)Cl>[CH2:1]([C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([CH3:9])[C:4]=1[N:10]1[C:18](=[O:19])[CH2:17][N:16]([CH:13]([CH3:15])[CH3:14])[C:11]1=[S:12])[CH3:2]

Komponenten

5

Edukt 3

HCID 8471TriethylamineHCID 1441882-Ethyl-6-methylphenyl isothiocyanateHCID 414244NoName_76

Produkt 1

HCID 857015313-(2-Ethyl-6-methylphenyl)-1-isopropyl-2-thioxo-imidazolidin-4-oneAusbeute 47,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel

Versuchsvorschrift

The title compound was prepared by the procedure described in Example 45 using 17.7 g of 2-ethyl-6-methylphenyl-isothiocyanate, 21.2 g of N-isopropyl glycine, 21.0 g of triethyl amine, and 300 mL of chloroform. Crystallization from ethanol afforded the title compound (13.0 g) as a light yellow solid, m.p. 132°-134° C. Anal. Calcd. for. C15H2O N2O S: C, 65.18; H, 7.29; N, 10.14. Found: C, 65.06; H, 7.37; N, 10.20. Mass spectrum (El, M.+) m/z 276.

Aufarbeitung

  1. customThe title compound was prepared by the procedure
  2. customCrystallization from ethanol

Quellen und Nachweise

ORD-Eintrag
ord-d62e6f8eb9d84c96b8eb7285ba8bb833
Quelldatensatz
uspto-grants-1996_09
Patentnummer
US05554607

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