Tetrahydrofuran → 2-(2-(3-(Morpholin-4-yl)-n-propyl)aminoanilin-4-yl)benzoxazole

HRID 74279Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 74279
N1(C(C)C[NH:9][C:10]2[CH:15]=[CH:14][C:13]([C:16]3[O:17][C:18]4[CH:24]=[CH:23][CH:22]=[CH:21][C:19]=4[N:20]=3)=[CH:12][C:11]=2[N+:25]([O-])=O)CCOCC1.[H][H].[O:31]1[CH2:35][CH2:34][CH2:33][CH2:32]1>[C].[Pd]>[N:9]1([CH2:10][CH2:11][CH2:12][NH:25][C:11]2[CH:12]=[C:13]([C:16]3[O:17][C:18]4[CH:24]=[CH:23][CH:22]=[CH:21][C:19]=4[N:20]=3)[CH:14]=[CH:15][C:10]=2[NH2:9])[CH2:34][CH2:35][O:31][CH2:32][CH2:33]1

Komponenten

5

Edukt 3

HCID 8028TetrahydrofuranHCID 674985632-(N-(2-(morpholin-4-yl)-n-propyl)-2-nitroanilin-4-yl)benzoxazoleHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 674982532-(2-(3-(Morpholin-4-yl)-n-propyl)aminoanilin-4-yl)benzoxazoleAusbeute 99 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 178418390HCID 178418390, VerbindungKatalysator

Versuchsvorschrift

To a solution of 2-(N-(2-(morpholin-4-yl)-n-propyl)-2-nitroanilin-4-yl)benzoxazole (see Working Example 96-1) (665 mg, 1.74 mmol) in tetrahydrofuran (10 mL) was added 10% palladium-carbon (70 mg). A hydrogen atmosphere was then substituted in the flask, and this was stirred at room temperature for 17 hours. After the reaction was finished, this was filtered through Celite, and the filtrate was concentrated to yield the title compound (605 mg, 99% yield).

Aufarbeitung

  1. filtrationthis was filtered through Celite
  2. concentrationthe filtrate was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-29eb486814c94c0e888b39ee379cfbf7
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08829035B2

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