[(4-Iodophenyl)sulfonyl]-2-pyridylamine → 2-Hydroxy-5-[2-[4-[(2-pyridinylamino)sulfonyl]phenyl]ethenyl]benzoic acid

HRID 743001Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 743001
[CH:1]([C:3]1[CH:4]=[CH:5][C:6]([OH:15])=[C:7]([CH:14]=1)[C:8]([O:10]C(C)C)=[O:9])=[CH2:2].I[C:17]1[CH:22]=[CH:21][C:20]([S:23]([NH:26][C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][N:28]=2)(=[O:25])=[O:24])=[CH:19][CH:18]=1>>[OH:15][C:6]1[CH:5]=[CH:4][C:3]([CH:1]=[CH:2][C:17]2[CH:18]=[CH:19][C:20]([S:23]([NH:26][C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][N:28]=3)(=[O:25])=[O:24])=[CH:21][CH:22]=2)=[CH:14][C:7]=1[C:8]([OH:10])=[O:9]

Komponenten

3

Edukt 2

HCID 1143526[(4-Iodophenyl)sulfonyl]-2-pyridylamineHCID 19423367Isopropyl 5-ethenyl-2-hydroxybenzoate

Produkt 1

HCID 543430162-Hydroxy-5-[2-[4-[(2-pyridinylamino)sulfonyl]phenyl]ethenyl]benzoic acidAusbeute 40 %

Versuchsvorschrift

Isopropyl 5-ethenyl-2-hydroxybenzoate was reacted with 4-iodo-N-(2-pyridinyl)benzenesulfonamide similarly to the procedure of Example 5c. After the reaction, the solvent was evaporated, toluene was added and the suspension filtered and washed with toluene. After drying on the filter and washing with water the material was hydrolyzed and precipitated similarly to the procedure of Example 3c. Yield 40%

Aufarbeitung

  1. customAfter the reaction
  2. customthe solvent was evaporated
  3. additiontoluene was added
  4. filtrationthe suspension filtered
  5. washwashed with toluene
  6. customAfter drying on the
  7. filtrationfilter
  8. washwashing with water the material
  9. customprecipitated similarly to the procedure of Example 3c

Quellen und Nachweise

ORD-Eintrag
ord-76e411d9c52446e183b5f60c4666df1f
Quelldatensatz
uspto-grants-1996_09
Patentnummer
US05556855

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