Hydrochloric Acid → 1-Methyl-2-{2-[2-(4-phenylbutyl)phenoxy]ethyl}pyrrolidine hydrochloride

HRID 743179

Reaktionsgleichung

Reaktionsgleichung von HRID 743179
[ClH:1].[CH3:2][N:3]1[CH2:7][CH2:6][CH2:5][CH:4]1[CH2:8][CH2:9][O:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[CH2:17][CH2:18][CH2:19][CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>O1CCOCC1.C(OCC)(=O)C>[ClH:1].[CH3:2][N:3]1[CH2:7][CH2:6][CH2:5][CH:4]1[CH2:8][CH2:9][O:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[CH2:17][CH2:18][CH2:19][CH2:20][C:21]1[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=1

Komponenten

5

Edukt 2

HCID 313Hydrochloric AcidHCID 106907751-Methyl-2-{2-[2-(4-phenylbutyl)phenoxy]ethyl}pyrrolidine

Produkt 1

HCID 194239751-Methyl-2-{2-[2-(4-phenylbutyl)phenoxy]ethyl}pyrrolidine hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 8857Ethyl AcetateLösungsmittelHCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

0.2 ml of a 4N solution of hydrogen chloride in dioxane was added to a solution of 130 mg of 1-methyl-2-{2-[2-(4-phenylbutyl)phenoxy]ethyl}pyrrolidine [prepared as described in step (a) above] in 5 ml of ethyl acetate, and the resulting mixture was worked up in a similar manner to the procedure described in Example 1(c). The solvent was removed by distillation under reduced pressure, and the residue was dried in vacuo, to give 144 mg of the title compound as a colorless oil.

Aufarbeitung

  1. customThe solvent was removed by distillation under reduced pressure
  2. customthe residue was dried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-f466fb14676e4f0598b0488db598de97
Quelldatensatz
uspto-grants-1996_09
Patentnummer
US05556864

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