1-(2-(2-(1-Benzothiophene-5-yl)ethoxy)ethyl)-3-azetidinol → 1-(2-(2-(1-Benzothiophene-5-yl)ethoxy)ethyl)-3-azetidinol hydrochloride

HRID 7437

Reaktionsgleichung

Reaktionsgleichung von HRID 7437
[S:1]1[C:5]2[CH:6]=[CH:7][C:8]([CH2:10][CH2:11][O:12][CH2:13][CH2:14][N:15]3[CH2:18][CH:17]([OH:19])[CH2:16]3)=[CH:9][C:4]=2[CH:3]=[CH:2]1.C(OCC)(=O)C.[ClH:26]>C(OCC)(=O)C>[ClH:26].[S:1]1[C:5]2[CH:6]=[CH:7][C:8]([CH2:10][CH2:11][O:12][CH2:13][CH2:14][N:15]3[CH2:18][CH:17]([OH:19])[CH2:16]3)=[CH:9][C:4]=2[CH:3]=[CH:2]1

Komponenten

4

Edukt 2

HCID 114042301-(2-(2-(1-Benzothiophene-5-yl)ethoxy)ethyl)-3-azetidinolHCID 21866389Hydrogen chloride-ethyl acetate

Produkt 1

HCID 114042291-(2-(2-(1-Benzothiophene-5-yl)ethoxy)ethyl)-3-azetidinol hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

In 4.2 mL of ethyl acetate was dissolved 1.03 g of 1-{2-[2-(1-benzothiophen-5-yl)ethoxy]ethyl}-3-azetidinol, and to the solution was added 0.86 mL of a 4.76 mol/L dried hydrogen chloride-ethyl acetate solution. The resulting mixture was stirred at room temperature for 1 hour and then at 5° C. for 1 hour. The crystals precipitated were collected by filtration, washed with ethyl acetate and then dried to obtain 0.98 g of 1-{2-[2-(1-benzothiophen-5-yl)ethoxy]ethyl}-3-azetidinol hydrochloride.

Aufarbeitung

  1. waitat 5° C. for 1 hour
  2. customThe crystals precipitated
  3. filtrationwere collected by filtration
  4. washwashed with ethyl acetate
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-9f6a0eda9df54bc286584a94be20d1da
Quelldatensatz
uspto-grants-2006_08
Patentnummer
US07087594B2

Verknüpfte Notizen

Wird geladen…