Dichloromethane → 1-Bromo-4-(tert-butoxy)benzene

HRID 743869Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 743869
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][CH:3]=1.[CH3:9][C:10](=[CH2:12])[CH3:11].C(Cl)Cl.FC(F)(F)S(O)(=O)=O>C(N(CC)CC)C>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][C:10]([CH3:12])([CH3:11])[CH3:9])=[CH:4][CH:3]=1

Komponenten

6

Edukt 4

HCID 6344DichloromethaneHCID 78084-BromophenolHCID 8255IsobutyleneHCID 62406Trifluoromethanesulfonic acid

Produkt 1

HCID 27639591-Bromo-4-(tert-butoxy)benzene

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8471TriethylamineLösungsmittel

Reaktionsbedingungen

Temperatur
-78 °C

Versuchsvorschrift

4-Bromophenol(57.8 moles, 10.0 g) was added to a -30° C. solution of isobutylene (40 ml) and methylene chloride (50 ml) and then cooled to -78° C. Trifluoromethanesulfonic acid (4 moles, 0.35 ml) was added. The mixture was held at -78° C. for 4 hours and then allowed to warm to room temperature. Triethylamine (0.5 ml) was added; the solvent was removed. The residue was chromatographed over silica gel eluted with 1% ethyl acetate in hexane to yield 12.4 g. (MS)

Aufarbeitung

  1. temperatureto warm to room temperature
  2. customthe solvent was removed
  3. customThe residue was chromatographed over silica gel
  4. washeluted with 1% ethyl acetate in hexane
  5. customto yield 12.4 g

Quellen und Nachweise

ORD-Eintrag
ord-80698780aef84de8bb93d1096584109c
Quelldatensatz
uspto-grants-1996_09
Patentnummer
US05556981

Notizen zur Reaktion

Wird geladen…