Cesium carbonate → 2-(3-(3-(((1R,2S)-2-hydroxycyclohexyl)methoxy)phenyl)propyl)isoindoline-1,3-dione

HRID 74402Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 74402
CC1C=CC(S([O:11][CH2:12][C@H:13]2[CH2:18][CH2:17][CH2:16][CH2:15][C@@H:14]2[OH:19])(=O)=O)=CC=1.O[C:21]1[CH:22]=[C:23]([CH2:27][CH2:28][CH2:29][N:30]2[C:38](=[O:39])[C:37]3[C:32](=[CH:33][CH:34]=[CH:35][CH:36]=3)[C:31]2=[O:40])[CH:24]=[CH:25][CH:26]=1.C(=O)([O-])[O-].[Cs+].[Cs+]>CN(C=O)C>[OH:19][C@H:14]1[CH2:15][CH2:16][CH2:17][CH2:18][C@@H:13]1[CH2:12][O:11][C:25]1[CH:24]=[C:23]([CH2:27][CH2:28][CH2:29][N:30]2[C:31](=[O:40])[C:32]3[C:37](=[CH:36][CH:35]=[CH:34][CH:33]=3)[C:38]2=[O:39])[CH:22]=[CH:21][CH:26]=1

Komponenten

5

Edukt 3

HCID 10796Cesium carbonateHCID 14970968((1R,2S)-2-hydroxycyclohexyl)methyl 4-methylbenzenesulfonateHCID 580275422-[3-(3-Hydroxyphenyl)propyl]isoindole-1,3-dione

Produkt 1

HCID 673164482-(3-(3-(((1R,2S)-2-hydroxycyclohexyl)methoxy)phenyl)propyl)isoindoline-1,3-dione

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Reaktionsbedingungen

Temperatur
60 °C

Versuchsvorschrift

A mixture of ((1R,2S)-2-hydroxycyclohexyl)methyl 4-methylbenzenesulfonate (0.334 g, 1.24 mmol), compound 58 (0.432 g, 1.54 mmol), cesium carbonate (0.562 g, 1.73 mmol) in anhydrous DMF (8 mL) was stirred at 60° C. under argon for 18 hrs, and then concentrated under reduced pressure. Water was added and the product was extracted with EtOAc three times. Combined fractions were washed with sat. NH4Cl, brine, and concentrated under reduced pressure. The residue was purified by flash chromatography (20% to 70% EtOAc/hexanes gradient) to afford 2-(3-(3-(((1R,2S)-2-hydroxycyclohexyl)methoxy)phenyl)propyl)isoindoline-1,3-dione as a colorless oil. Yield (0.191 g, 41%). 1H NMR (400 MHz, DMSO-d6) δ 7.76-7.85 (m, 4H), 7.09 (t, 7.6 Hz, 1H), 6.69-6.74 (m, 2H), 6.61-6.65 (m, 1H), 4.34 (d, J=4.1 Hz, 1H), 3.91 (dd, J=7.0, 9.2 Hz, 1H), 3.86-3.89 (m, 1H), 3.67 (dd, J=6.9, 9.2 Hz, 1H), 3.53-3.60 (m, 2H), 2.50 (t, J=7.6 Hz, 2H), 1.80-1.91 (m, 2H), 1.73-1.80 (m, 1H), 1.51-1.66 (m, 3H), 1.28-1.44 (m, 4H), 1.17-1.25 (m, 1H).

Aufarbeitung

  1. concentrationconcentrated under reduced pressure
  2. additionWater was added
  3. extractionthe product was extracted with EtOAc three times
  4. washCombined fractions were washed with sat. NH4Cl, brine
  5. concentrationconcentrated under reduced pressure
  6. customThe residue was purified by flash chromatography (20% to 70% EtOAc/hexanes gradient)

Quellen und Nachweise

ORD-Eintrag
ord-b7bc1e6090d345c29bf2a959cd3fe97a
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08829244B2

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