HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Methanol → 3-Benzyloxycarbonylamino-2(r,s)-methylpropionic acid methyl ester
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Methanol | HCID 887 | — |
| Edukt | 3-(((Benzyloxy)carbonyl)amino)-2-methylpropanoic acid | HCID 304274 | — |
| Katalysator | Sulfuric Acid | HCID 1118 | — |
| Produkt | 3-Benzyloxycarbonylamino-2(r,s)-methylpropionic acid methyl ester | HCID 22364470 | — |
Reaktionsschritte
22.6 g of 3-benzyloxycarbonylamino-2(R,S)-methylpropionic acid are left to stand for 24 hours in 230 ml of methanol with a few drops of concentrated sulfuric acid. The reaction mixture is concentrated by evaporation and the residue is purified by FC (220 g of silica gel, dichloromethane). The title compound is obtained: Rf (dichloromethane/methanol=95:5)=0.60.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US05559111 |
| Quelldatensatz | uspto-grants-1996_09 |
| ORD ID | ord-cc8983031c1e457db04f9006e1139e60 |
| Quellennotiz | uspto-grants-1996_09 |