Hydrochloric Acid → N'-Phenylcyclobutanecarbohydrazide

HRID 74518Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 74518
[CH:1]1([C:5](Cl)=[O:6])[CH2:4][CH2:3][CH2:2]1.[C:8]1([NH:14][NH2:15])[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.N1C=CC=CC=1.Cl>CN(C=O)C>[C:8]1([NH:14][NH:15][C:5]([CH:1]2[CH2:4][CH2:3][CH2:2]2)=[O:6])[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

Komponenten

6

Edukt 4

HCID 313Hydrochloric AcidHCID 1049PyridineHCID 7516PhenylhydrazineHCID 78705Cyclobutanecarbonyl chloride

Produkt 1

HCID 13728291N'-Phenylcyclobutanecarbohydrazide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

3.54 mL (31.0 mmol) cyclobutanecarboxylic acid chloride were added dropwise at RT to 3.00 mL (30.2 mmol) phenylhydrazine and 4.75 mL (60.0 mmol) pyridine in 30 mL DMF. The mixture was stirred for 1 h at RT and poured onto 200 mL of a 1M hydrochloric acid solution. The precipitated solid was suction filtered, washed with 50 mL water and dried i. vac. The product was extracted with 50 mL ether and suction filtered. The solid was washed with 20 mL ether and dried in the air.

Aufarbeitung

  1. filtrationfiltered
  2. washwashed with 50 mL water
  3. customdried i
  4. extractionThe product was extracted with 50 mL ether and suction
  5. filtrationfiltered
  6. washThe solid was washed with 20 mL ether
  7. customdried in the air

Quellen und Nachweise

ORD-Eintrag
ord-751690bac2704318a4bd743d93e918ee
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08829006B2

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