HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
1H-Indole-3-propanoic acid → 3-(1H-indol-3-yl)-1-(pyrrolidin-1-yl)propan-1-one
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 1H-Indole-3-propanoic acid | HCID 3744 | — |
| Edukt | Triethylamine | HCID 8471 | — |
| Edukt | Pyrrolidine | HCID 31268 | — |
| Edukt | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Lösungsmittel | Dimethylformamide | HCID 6228 | — |
| Produkt | 3-(1H-indol-3-yl)-1-(pyrrolidin-1-yl)propan-1-one | HCID 4806783 | — |
Reaktionsschritte
681 mg (3.60 mmol) 3-(1H-indol-3-yl)-propionic acid, 0.3 mL (3.60 mmol) pyrrolidine, 1.13 g (3.50 mmol) TBTU and 0.98 mL (7.00 mmol) triethylamine in 5.0 mL DMF were stirred overnight at RT. The mixture was purified by preparative HPLC. The product fractions were combined and evaporated down i. vac.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08829006B2 |
| Quelldatensatz | uspto-grants-2014_09 |
| ORD ID | ord-1df2c89023ab44e3bf397e899e470f39 |
| Quellennotiz | uspto-grants-2014_09 |