Hydrochloric Acid → N-[4-{4-(2-pyrimidinyl)-1-piperazinyl}butyl]cyclohexane-1,2-dicarboximide hydrochloride

HRID 745213

Reaktionsgleichung

Reaktionsgleichung von HRID 745213
Br[CH2:2][CH2:3][CH2:4][CH2:5][N:6]1[C:15](=[O:16])[CH:10]2[CH2:11][CH2:12][CH2:13][CH2:14][CH:9]2[C:7]1=[O:8].[N:17]1[CH:22]=[CH:21][CH:20]=[N:19][C:18]=1[N:23]1[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]1.C(=O)([O-])[O-].[K+].[K+].[ClH:35]>CN(C)C=O>[ClH:35].[N:17]1[CH:22]=[CH:21][CH:20]=[N:19][C:18]=1[N:23]1[CH2:28][CH2:27][N:26]([CH2:2][CH2:3][CH2:4][CH2:5][N:6]2[C:15](=[O:16])[CH:10]3[CH2:11][CH2:12][CH2:13][CH2:14][CH:9]3[C:7]2=[O:8])[CH2:25][CH2:24]1

Komponenten

6

Edukt 4

HCID 313Hydrochloric AcidHCID 11430Potassium CarbonateHCID 887471-(2-Pyrimidinyl)piperazineHCID 13671565N-(4-bromobutyl)cyclohexane-1,2-dicarboximide

Produkt 1

HCID 23315240N-[4-{4-(2-pyrimidinyl)-1-piperazinyl}butyl]cyclohexane-1,2-dicarboximide hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

A mixture of N-(4-bromobutyl)cyclohexane-1,2-dicarboximide (10.00 g), 1-(2-pyrimidyl)piperazine (4.75 g), anhydrous potassium carbonate powder (8.00 g) and anhydrous dimethylformamide (100 ml) was stirred at 100°-110° C. for 9 hours. The solvent was removed from the reaction mixture under reduced pressure, and the residue was purified by chromatography to give an oily substance, which was then treated with hydrogen chloride to give N-[4-{4-(2-pyrimidinyl)-1-piperazinyl}butyl]cyclohexane-1,2-dicarboximide hydrochloride. M.P., 168°-169° C.

Aufarbeitung

  1. customThe solvent was removed from the reaction mixture under reduced pressure
  2. customthe residue was purified by chromatography
  3. customto give an oily substance, which

Quellen und Nachweise

ORD-Eintrag
ord-6b35f752576b44fe9eb2069991caa63c
Quelldatensatz
uspto-grants-1986_07
Patentnummer
US04598078

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