Methanol → 2H-Indol-2-one, 5-fluoro-1,3-dihydro-3-Methyl-
Reaktionsgleichung
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[CH2:5]2.[CH3:12]O>[Ni]>[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[CH:5]2[CH3:12]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
3.0 g (20 mmol) 5-fluoro-1,3-dihydro-indol-2-one were stirred with 2.0 g Raney nickel in 50 mL methanol for 1.5 h at 200° C. in an autoclave. The catalyst was filtered off and the filtrate was concentrated to dryness by rotary evaporation. The residue was recrystallised from methanol, suction filtered and dried.
Aufarbeitung
- filtrationThe catalyst was filtered off
- concentrationthe filtrate was concentrated to dryness by rotary evaporation
- customThe residue was recrystallised from methanol, suction
- filtrationfiltered
- customdried
Quellen und Nachweise
- ORD-Eintrag
- ord-dcdde16e51c549069ef8eb150764399d
- Quelldatensatz
- uspto-grants-2014_09
- Patentnummer
- US08829006B2
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