[CH3:1][CH:2]([C:4]1[CH:5]=[C:6]2[C:11](=[C:12]([CH:14]([CH3:16])[CH3:15])[CH:13]=1)[N:10]=[CH:9][NH:8][C:7]2=[O:17])[CH3:3].[CH3:18][O:19][C:20](=[O:24])/[CH:21]=[CH:22]\Cl.C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[CH3:18][O:19][C:20](=[O:24])/[CH:21]=[CH:22]/[N:8]1[C:7](=[O:17])[C:6]2[C:11](=[C:12]([CH:14]([CH3:16])[CH3:15])[CH:13]=[C:4]([CH:2]([CH3:1])[CH3:3])[CH:5]=2)[N:10]=[CH:9]1A mixture of 3.10 g (0.013)mol) of 6,8-bis-(1-methylethyl)-quinazolin-4(3H)-one, 1.78 g (0.0148 mol) of (Z)-3-chloro-2-propenoic acid methyl ester and 3.72 g (0.027 mol) of anhydrous potassium carbonate in 100 ml. of anhydrous acetone was stirred at reflux for 17 hr. The reaction mixture was filtered, the solid was washed with acetone and the filtrate was concentrated in vacuo to an oil which soon crystallized. Recrystallization from methanol gave 3.11 g, m.p. 102°-103°, (74% yield) of (E)-3-[6,8-bis-(1-methylethyl)-4-oxo-4H-quinazolin-3-yl]-2-propenoic acid methyl ester.
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