Potassium Carbonate → HCID 23313832, Verbindung

Reaktionsgleichung

[C:1]([S:4][CH2:5][CH2:6][C:7](Cl)=[O:8])(=[O:3])[CH3:2].[CH3:10][C:11]1([CH3:23])[C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[NH:13][CH:12]1[C:20]([NH2:22])=[O:21].C(=O)([O-])[O-].[K+].[K+]>C(Cl)Cl>[C:1]([S:4][CH2:5][CH2:6][C:7]([N:13]1[C:14]2[C:19](=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:11]([CH3:10])([CH3:23])[CH:12]1[C:20]([NH2:22])=[O:21])=[O:8])(=[O:3])[CH3:2]

Komponenten

Versuchsvorschrift

The solution of 0.052 g of 3-acetylthiopropanoyl chloride in 1 ml of methylene chloride is added slowly to the mixture of 60 mg of 3,3-dimethylindoline-2-carboxamide, 87 mg of potassium carbonate and 9 ml of methylene chloride. The mixture is stirred at room temperature overnight, diluted with methylene chloride and filtered. The filtrate is washed with saturated aqueous sodium bicarbonate, water, 0.5N hydrochloric acid and water, dried, evaporated and the residue crystallized from diethyl ether, to yield the 1-(3-acetylthiopropanoyl)-3,3-dimethylindoline-2-carboxamide melting at 156°-158°.