methyl (4-nitro-2,3-dihydro-1H-indol-3-yl)-acetate → HCID 10104433, Verbindung

HRID 74573

Reaktionsgleichung

Reaktionsgleichung von HRID 74573
[N+:1]([C:4]1[CH:12]=[CH:11][CH:10]=[C:9]2[C:5]=1[CH:6]([CH2:13][C:14]([O:16][CH3:17])=[O:15])[CH2:7][NH:8]2)([O-])=O.[H][H]>CO.[Ni]>[NH2:1][C:4]1[CH:12]=[CH:11][CH:10]=[C:9]2[C:5]=1[CH:6]([CH2:13][C:14]([O:16][CH3:17])=[O:15])[CH2:7][NH:8]2

Komponenten

5

Edukt 2

HCID 10243182methyl (4-nitro-2,3-dihydro-1H-indol-3-yl)-acetateHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 10104433HCID 10104433, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 935NickelKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

2.0 g (8.5 mmol) methyl (4-nitro-2,3-dihydro-1H-indol-3-yl)-acetate in 70 mL MeOH were combined with 0.30 g Raney nickel and hydrogenated for 2 h in a hydrogen atmosphere. The catalyst was removed by suction filtering and the solution was concentrated by rotary evaporation. The residue was immediately reacted further without further purification.

Aufarbeitung

  1. customThe catalyst was removed by suction
  2. filtrationfiltering
  3. concentrationthe solution was concentrated by rotary evaporation
  4. customThe residue was immediately reacted further without further purification

Quellen und Nachweise

ORD-Eintrag
ord-5ff40530b07748d5b45375c1bd584cf4
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08829006B2

Verknüpfte Notizen

Wird geladen…