O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate → HCID 58386545, Verbindung

HRID 74586

Reaktionsgleichung

Reaktionsgleichung von HRID 74586
[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([N:11]([S:13]([CH3:16])(=[O:15])=[O:14])[CH3:12])[N:10]=1)[C:5]([OH:7])=O.[F:17][C:18]1[CH:19]=[C:20]2[C:24](=[CH:25][CH:26]=1)[NH:23][CH2:22][CH2:21]2.CN(C(ON1N=NC2C=CC=CC1=2)=[N+](C)C)C.[B-](F)(F)(F)F>CN(C=O)C>[Cl:1][C:2]1[N:10]=[C:9]([N:11]([CH3:12])[S:13]([CH3:16])(=[O:15])=[O:14])[CH:8]=[C:4]([C:5]([N:23]2[C:24]3[C:20](=[CH:19][C:18]([F:17])=[CH:26][CH:25]=3)[CH2:21][CH2:22]2)=[O:7])[CH:3]=1

Komponenten

5

Edukt 3

HCID 2733207O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborateHCID 27744635-FluoroindolineHCID 167483252-Chloro-6-[methyl(methylsulfonyl)amino]isonicotinic acid

Produkt 1

HCID 58386545HCID 58386545, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

0.30 g (1.1 mmol) 2-chloro-6-(methanesulphonyl-methyl-amino)-isonicotinic acid, 0.16 g (1.1 mmol) 5-fluoro-2,3-dihydro-1H-indole, 0.31 mL (2.2 mmol) TEA in 4.0 mL DMF were mixed with 0.39 g (1.2 mmol) TBTU and stirred for 2 h at RT. The reaction mixture was purified by HPLC. The product fractions were combined and evaporated down.

Aufarbeitung

  1. customThe reaction mixture was purified by HPLC
  2. customevaporated down

Quellen und Nachweise

ORD-Eintrag
ord-63e1edc9b42548fb9d6457cf084a43a5
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08829006B2

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