Sodium Hydroxide → 2-ethyl-1H-indole

HRID 74589Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 74589
C1(S([N:10]2[C:18]3[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=3)[CH:12]=[C:11]2[CH2:19][CH3:20])(=O)=O)C=CC=CC=1.[OH-].[Na+]>CCO>[CH2:19]([C:11]1[NH:10][C:18]2[C:13]([CH:12]=1)=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH3:20]

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 100167951H-Indole, 2-ethyl-1-(phenylsulfonyl)-

Produkt 1

HCID 38016182-ethyl-1H-indole

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

1.2 g (4.2 mmol) 1-benzenesulphonyl-2-ethyl-1H-indole in 10 mL EtOH were combined with 5 mL of a (20 mmol) 4 N aqueous sodium hydroxide solution and refluxed for 8 h. Then the solvent was eliminated using the rotary evaporator and the residue was diluted with ice water. After acidifying with semi-concentrated aqueous hydrochloric acid the grease precipitated was extracted with ethyl acetate. The organic phase was dried on sodium sulphate, filtered off, evaporated down and dried.

Aufarbeitung

  1. temperaturerefluxed for 8 h
  2. customthe rotary evaporator
  3. additionthe residue was diluted with ice water
  4. customprecipitated
  5. extractionwas extracted with ethyl acetate
  6. customThe organic phase was dried on sodium sulphate
  7. filtrationfiltered off
  8. customevaporated down
  9. customdried

Quellen und Nachweise

ORD-Eintrag
ord-003399a254d34568b19bee9374dea228
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08829006B2

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