Ethanol → HCID 20240708, Verbindung

HRID 746115Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 746115
[CH3:1][N:2]1[C:9](=[O:10])[CH:8]([C:11]([O:13]CC)=O)[C:6](=[O:7])[N:5]([CH3:16])[C:3]1=[O:4].[F:17][C:18]([F:34])([F:33])[C:19]1[CH:20]=[CH:21][C:22]([O:25][C:26]2[CH:32]=[CH:31][C:29]([NH2:30])=[CH:28][CH:27]=2)=[N:23][CH:24]=1.C(O)C>C1(C)C=CC=CC=1>[CH3:16][N:5]1[C:6](=[O:7])[CH:8]([C:11](=[O:13])[NH:30][C:29]2[CH:31]=[CH:32][C:26]([O:25][C:22]3[CH:21]=[CH:20][C:19]([C:18]([F:34])([F:17])[F:33])=[CH:24][N:23]=3)=[CH:27][CH:28]=2)[C:9](=[O:10])[N:2]([CH3:1])[C:3]1=[O:4]

Komponenten

5

Edukt 3

HCID 702EthanolHCID 5937141,3-Dimethyl-5-ethoxycarbonylbarbituric acidHCID 27830854-{[5-(Trifluoromethyl)pyridin-2-yl]oxy}aniline

Produkt 1

HCID 20240708HCID 20240708, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Versuchsvorschrift

1.60 g (0.007 mol) of 1,3-dimethyl-5-ethoxycarbonylbarbituric acid and 1.78 g (0.007 mol) of 4-(5-trifluoromethylpyrid-2-yloxy)aniline are suspended in 20 ml of toluene. The suspension is heated to reflux for 16 hours, during which time ethanol escapes. After cooling, the precipitate is isolated by filtration, washed with toluene and dried, affording 1,3-dimethyl-5-[4-(5-trifluoromethylpyrid-2-yloxy)phenylcarbamoyl]barbituric acid of the formula ##STR24## with a melting point of 180°-181° C.

Aufarbeitung

  1. temperatureThe suspension is heated
  2. temperatureAfter cooling
  3. customthe precipitate is isolated by filtration
  4. washwashed with toluene
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-ad9e6b3518fe46199102c704e4503b77
Quelldatensatz
uspto-grants-1986_07
Patentnummer
US04602912

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