3-Chlorophenylboronic acid ethylene glycol ester → (3-Chlorophenyl)(3,4-dimethoxyphenyl)borinic acid

HRID 746478Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 746478
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([Mg]Br)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10].[B:13](OCCO)([OH:21])[C:14]1[CH:19]=[CH:18][CH:17]=[C:16]([Cl:20])[CH:15]=1>>[Cl:20][C:16]1[CH:15]=[C:14]([B:13]([C:5]2[CH:6]=[CH:7][C:8]([O:9][CH3:10])=[C:3]([O:2][CH3:1])[CH:4]=2)[OH:21])[CH:19]=[CH:18][CH:17]=1

Komponenten

3

Edukt 2

HCID 692083603-Chlorophenylboronic acid ethylene glycol esterHCID 178491916HCID 178491916, Verbindung

Produkt 1

HCID 69207503(3-Chlorophenyl)(3,4-dimethoxyphenyl)borinic acid

Versuchsvorschrift

(3-Chlorophenyl)(3,4-dimethoxyphenyl)borinic acid was prepared from 3,4-dimethoxyphenylmagnesium bromide and 3-chlorophenylboronic acid ethylene glycol ester by the procedure described in Example 6a. The title complex product was made by the methodology described in Section 5.3.7.1, and obtained as yellow crystals. MS (ESI, positive): m/z=404 (M+1); 1H NMR (DMSO-d6, 300 MHz): δ 9.17 (d, 1H), 8.78 (d, 1H), 7.90 (dd, 1H), 7.70 (t, 1H), 7.43 (d, 1H), 7.30-7.17 (m, 5H), 6.89-6.80 (m, 3H), 3,66 (s, 3H) and 3.62 (s, 3H) ppm.

Aufarbeitung

  1. customobtained as yellow crystals

Quellen und Nachweise

ORD-Eintrag
ord-44af01f9e8b24b36b3e2c4716540a207
Quelldatensatz
uspto-grants-2008_07
Patentnummer
US07393856B2

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