Hydrochloric Acid → HCID 69212897, Verbindung

HRID 746655Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 746655
[CH3:1][N:2]1[C:7](=[O:8])[C:6]2[C:9]([C:13]([O:15]C)=[O:14])=[C:10]([CH3:12])[S:11][C:5]=2[N:4]([CH:17]([CH3:19])[CH3:18])[C:3]1=[O:20].CO.[OH-].[Na+].Cl>C1COCC1>[CH3:1][N:2]1[C:7](=[O:8])[C:6]2[C:9]([C:13]([OH:15])=[O:14])=[C:10]([CH3:12])[S:11][C:5]=2[N:4]([CH:17]([CH3:18])[CH3:19])[C:3]1=[O:20]

Komponenten

6

Edukt 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 14798Sodium HydroxideHCID 17974723Methyl 1-isopropyl-3,6-dimethyl-2,4-dioxo-1,2,3,4-tetrahydrothieno(2,3-d)pyrimidine-5-carboxylate

Produkt 1

HCID 69212897HCID 69212897, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To a solution of the product of step b) (3.81 g) in THF (50 ml) and methanol (5 ml) was added 1N NaOH (25.7 ml) and the mixture stirred under nitrogen for 18 hr. It was acidified with 2.5N HCl and extracted with DCM, the organic extracts washed with water, dried over anhydrous magnesium sulfate, filtered and evaporated under reduced pressure to give the sub-title compound as a solid (3.40 g)

Aufarbeitung

  1. extractionextracted with DCM
  2. washthe organic extracts washed with water
  3. dry with materialdried over anhydrous magnesium sulfate
  4. filtrationfiltered
  5. customevaporated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-c2b9f90ec9374a2dacf5dea18b7b4e5a
Quelldatensatz
uspto-grants-2008_07
Patentnummer
US07393854B2

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